DIABETES AND METABOLIC POLYNEUROPATHY: FROM STUDIES TO CLINICAL PRACTICE
Maret 17, 2011
Diabetes Mellitus (DM) is estimated by WHO in 2000 has a prevalence of 150 million, and in 2030 is expected to increase by 366 million (Wild et al., 2004). Neuropathy is a very common complication characterized by symptoms characteristic of the loss of peripheral nerve fibers in a progressive (Boulton et al., 2004). There are several clinical manifestations including mononeuropati neuropathy or polyneuropathy. In DM patients the common people with diabetic foot is the distal sensory polyneuropathy. Even so often accompanied by disturbances of motor and autonomic nerve fibers. The occurrence of neuropathy associated with poor glycemic control, and the incidence generally increased with increasing age and longer duration of DM.
DM clinic descriptive research profile on Installation Diabetes Outpatient Clinic at Hospital Dr.Soetomo of 51% (1333 of 2609 people) DM patients have complaints incidence of peripheral neuropathy and / or parastesia. In patients in the Inpatient Ward Hospital Medicine Section Dr.Soetomo recorded 90.03% of neuropathy in diabetic patients with diabetic foot complications (Soegiarto et al, 1998).
Data epidemiology and course of the disease Diabetic neuropathy showed varying numbers, and is a common medical problem faced by patients. Several studies neuropathy prevalence in outpatients is estimated that 30% (Young et al., 1993), while the prevalence in the general population is estimated to 20 (Kumar et al., 1994; Cabesas, 1998; Abbot et al., 2002; Walters et al., 1992; Dyck et al., 1993; Boyko 1998). In old age the prevalence could reach 50% (Boulton et al., 2004; Kumar et al., 1994). In a variety of population prevalence rate ranging from 14% to 63% depending on the criteria of neuropathy dipergunskan (Walters et al., 1992). In EURODIABIDDM Complications Study (Tesfaye et al., 1996) with a total sample of 3250 patients, the mean prevalence rate of neuropathy in 16 European countries reached 16%. In the Rochester Diabetic Neuropathy Study Study (Dyck et al., 1993), reported a 60% neuropathy patients, although only 15% are symptomatic.
This paper briefly discussed the development of pain management and treatment of symptoms associated with Diabetic Neuropathy.